MTHFR

Methylenetetrahydrofolate reductase – the key enzyme of the methyl cycle, it catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate that results in the methylation of homocysteine with methionine as the end product. Mutations in the gene producing this enzyme have been associated with cancers and neural tube defects among other things.