Tap on and choose 'Add to Home Screen' to create a shortcut app

Tap on and choose 'Add to Home Screen/Install App' to create a shortcut app

Adjuvant Therapies for Syndromic Craniosynostosis in Children

This page was last updated on May 9th, 2017

There are to date no real treatment alternatives to surgery for children with syndromic craniosynostosis.

Cranial Orthotic Molding Therapy

  • Not effective: Molding helmets are not effective in syndromic multisutural craniosynostosis and are not recommended unless a minimally invasive route is taken.

Genetic Counseling

  • Dominant inheritance: The common craniosynostosis syndromes all show dominant inheritance and a relatively high proportion of new mutations.
  • Difficulty in establishing point of mutation: Genetic counseling for the parents of a child with an apparently new mutation can be made difficult by uncertainties over the recurrence risk attributable to occult germline mosaicism in a parent. The mosaicism might be either in the patient, indicating a very low recurrence risk for the parents, or in a parent, indicating an offspring risk to daughters of up to 50% if the mother is the mosaic or up to 100% if the father is the mosaic.
  • Difficult to establish indication of syndromes in in-utero screening: In contrast to the presence of an EFNB1 mutation, the recurrence risk is low for parents with a child with an FGFR mutation. FGFR mutations seem to arise because of a selective advantage of the mutation in spermatogonial stem cells after puberty. While this gives rise to the exceptionally high apparent rates observed for specific mutations in the FGFR genes, the origin of these mutations in adulthood means that they are unlikely to reach sufficient levels in sperm to make recurrence a likely possibility (47, 48). Therefore, the risk-benefit ratio of genetic prenatal diagnosis needs to be weighed carefully before proceeding with an invasive diagnostic procedure on the fetus.

Your donations keep us going

The ISPN Guide is free to use, but we rely on donations to fund our ongoing work and to maintain more than a thousand pages of information created to disseminate the most up-to-date knowledge in the field of paediatric neurosurgery.

By making a donation to The ISPN Guide you are also indirectly helping the many thousands of children around the world whose treatment depends on well-informed surgeons.

Please consider making a donation today.

Use the app

The ISPN Guide can be used as a standalone app, both on mobile devices and desktop computers. It’s quick and easy to use.

Fully featured

Free registration grants you full access to The Guide and host of featured designed to help further your own education.

Stay updated

The ISPN Guide continues to expand both in breadth and depth. Join our mailing list to stay up-to-date with our progress.