Tap on and choose 'Add to Home Screen' to create a shortcut app

Tap on and choose 'Install/Install App' to create a shortcut app

Radiological Features of Mucopolysaccharidoses

This page was last updated on May 9th, 2017

General Findings

  • Flat vertebral bodies: The vertebrae are flattened and bullet shaped (platyspondyly).
  • Thick ligament at C1: There is ligamentous thickening behind the odontoid process, which may extend further down the cervical spinal canal.
  • Stenotic canal: The spinal canal is narrowed, particularly adjacent to regions of increased motion, e.g., the craniovertebral junction and midcervical spinal canal.
  • Thoracolumbar gibbus: This condition is common and often requires instrumented stabilization.

CT Scan

CT scan of cervical spine in a child with Morquio syndrome: The sagittal reformat shows odontoid hypoplasia and forward subluxation of C1.



While craniovertebral changes occur in mucopolysaccharidoses types I, II, and VI, patients with Morquio syndrome (type IV) are at particular risk from the combination of these morphological changes and instability (32, 33).

  • Dysplasia of the cervical spine: Odontoid hypoplasia, incomplete C1 ring formation, and platyspondyly are common features.
  • Pannus formation: Soft tissue thickening behind odontoid process (“pannus”) is apparent.
  • Spinal canal stenosis

T2-weighted MRI scan of the cervical spine of a child with Morquio syndrome: Ligamentous thickening is apparent at the craniovertebral junction.



Your donations keep us going

The ISPN Guide is free to use, but we rely on donations to fund our ongoing work and to maintain more than a thousand pages of information created to disseminate the most up-to-date knowledge in the field of paediatric neurosurgery.

By making a donation to The ISPN Guide you are also indirectly helping the many thousands of children around the world whose treatment depends on well-informed surgeons.

Please consider making a donation today.

Use the app

The ISPN Guide can be used as a standalone app, both on mobile devices and desktop computers. It’s quick and easy to use.

Fully featured

Free registration grants you full access to The Guide and host of featured designed to help further your own education.

Stay updated

The ISPN Guide continues to expand both in breadth and depth. Join our mailing list to stay up-to-date with our progress.