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Outcome of Therapies for Metabolic Bone Disease in Children

This page was last updated on May 9th, 2017

Outcome After Surgery

  • Advanced symptoms = poor prognosis: Children with advanced neurological symptoms at the time of intervention have a worse prognosis.
  • Decompression successful for most: Craniovertebral decompression ameliorates symptoms of cervicomedullary compression (neurological and respiratory) in most children with achondroplasia (3).
  • Fusion successful for 90%: Successful fusion can be anticipated in up to 90% of children wtih skeletal dysplasia (1, 7).
  • Instability adjacent to fusion for 1/3: Junctional instability below a previous successful fusion has been reported in up to one third of children with Morquio syndrome, thereby underscoring the importance of long-term follow-up (7).

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