Understanding of Disease
- 1895 – Von Hippel: In 1895 von Hippel published the description of angiomatosis of the retina of the eye (60).
- 1926 – Lindau: In 1926 Lindau, a Swedish pathologist, described a familial condition including tumors of the blood vessels of the eye and of the CNS (61). Cushing subsequently coined the term Lindau’s disease to describe a hemangioma of the cerebellum that he operated on in a patient who also had a hemangioma of the retina (62).
- Better classification using immunochemistry: Initially classified among “tumors of blood vessel origin” because of their characteristic capillary network, hemangioblastomas currently are classified among “tumors of the meninges” as a result of the development of immunohistochemistry.
- Genetic markers for VHL: Molecular pathology analysis has determined the association with VHL.
- Neuroradiology for better diagnosis and treatment: Progress in neuroimaging has made the diagnosis of hemangioblastoma very accurate. Interventional radiology may aid surgical management through preoperative embolization.
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