Cite

Copy

Tap on and choose 'Add to Home Screen' to create a shortcut app

Tap on and choose 'Install/Install App' to create a shortcut app

Epidemiology of Cerebral Arteriovenous Malformations in Children

This page was last updated on May 9th, 2017

Incidence and Prevalence

  • 1.4% in 3200 autopsies: In a large autopsy series, the overall frequency of detection of AVMs was 1.4% (46 among 3,200 unselected brain tumor cases) (3).
  • 1.1 per 100,000/year: In another report, the annual incidence of symptomatic AVMs was 1.1 per 100,000 (6).
  • 0.02% prevalence in children: The pediatric age group comprises 12–18% of all AVMs from major centers, and the overall prevalence in children is about 0.02% of the pediatric population (7–10).

Age Distribution

  • Mean age at diagnosis 30–40 years: Most AVMs present in adulthood, with a mean age at presentation of approximately 30-40 years.  About 20% of all symptomatic AVMs present before 15 years of age (11).

Sex Predilection

  • None: There is no sex predilection for pediatric AVMs.

Geographic Distribution

  • Possibly more frequent in Asians: AVMs are about one-seventh as common as saccular aneurysms; they may be more frequent in Asian populations (12).

Risk Factors

  • None

Relationships to Other Disease States and Syndromes

  • Hemorrhagic telangiectasia: The association of AVMs with HHT has been documented In one study, 35% of cases were associated with HHT and 23% of persons had multiple AVMs; the mean age at presentation was 35 years (6).
  • RASA1 mutation: The RASA1 mutation, resulting in familial AVMs and/or cutaneous capillary malformations, has been associated with symptomatic cerebral AVMs in a small number of families (13).

Your donations keep us going

The ISPN Guide is free to use, but we rely on donations to fund our ongoing work and to maintain more than a thousand pages of information created to disseminate the most up-to-date knowledge in the field of paediatric neurosurgery.

By making a donation to The ISPN Guide you are also indirectly helping the many thousands of children around the world whose treatment depends on well-informed surgeons.

Please consider making a donation today.

Use the app

The ISPN Guide can be used as a standalone app, both on mobile devices and desktop computers. It’s quick and easy to use.

Fully featured

Free registration grants you full access to The Guide and host of featured designed to help further your own education.

Stay updated

The ISPN Guide continues to expand both in breadth and depth. Join our mailing list to stay up-to-date with our progress.