Cite

Copy

Tap on and choose 'Add to Home Screen' to create a shortcut app

Tap on and choose 'Install/Install App' to create a shortcut app

Chemotherapy for Supratentorial PNETs in Children

This page was last updated on May 9th, 2017

Treatment

Adjuvant Therapy

Complications

Outcome

  • 30–60% cure rate: The general cure rate varies from 30–60% as a function of the tumor’s location. Tumors in the pineal location have a worse prognosis than do those arising in the CNS parenchyma. The inferior cure rate of this disease is likely related to a different underlying molecular biology than that of medulloblastoma despite the similar histology of the two tumors (50).
  • More intense chemotherapy may improve prognosis: In a recent report describing the treatment of a small cohort of 16 children with a more intense chemotherapeutic regimen coupled with a lowering of radiation to 23.4 Gy, 5-year EFS rates were 75% for those with <1.5 cm2 residual tumor after surgery and no dissemination (standard risk) and 60% for those with residual disease or dissemination (high risk) (8). The 5-year EFS rates for patients with pineal and non-pineal tumors were 54 ± 26% and 78 ± 14%, respectively.
  • Infants fare worse than older children: Infants treated with protocols of intensive chemotherapy alone had an overall 5-year EFS rate of 39%. Those with tumors in the pineal region had a 5-year EFS rate of 16%. These outcomes have resulted in the consideration of involved field radiation following submyeloablative therapy in this challenging group (15).

Your donations keep us going

The ISPN Guide is free to use, but we rely on donations to fund our ongoing work and to maintain more than a thousand pages of information created to disseminate the most up-to-date knowledge in the field of paediatric neurosurgery.

By making a donation to The ISPN Guide you are also indirectly helping the many thousands of children around the world whose treatment depends on well-informed surgeons.

Please consider making a donation today.

Use the app

The ISPN Guide can be used as a standalone app, both on mobile devices and desktop computers. It’s quick and easy to use.

Fully featured

Free registration grants you full access to The Guide and host of featured designed to help further your own education.

Stay updated

The ISPN Guide continues to expand both in breadth and depth. Join our mailing list to stay up-to-date with our progress.