Cite

Copy

Tap on and choose 'Add to Home Screen' to create a shortcut app

Tap on and choose 'Add to Home Screen/Install App' to create a shortcut app

Evaluation of Supratentorial Ependymomas in Children

This page was last updated on May 9th, 2017

Examination

A detailed history about the onset of symptoms and signs must be obtained, followed by a clinical examination to determine the level of consciousness (GCS score), to assess for signs of elevation in the ICP, and to screen for neurologic deficits.

Laboratory Tests

Standard blood tests are used by the author to prepare patients for surgery, such as complete blood count, electrolytes, coagulation times and cross-match, in case transfusion is required.

Radiologic Tests

CT Scan

There is a limited need for CT scans. 

  • Emergency: Sometimes CT is the imaging modality for the initial diagnosis.
  • Calcification: CT demonstrates calcifications better than MRI.

Axial CT scan, enhanced: The scan shows a right frontal tumor, with brain edema and areas of calcification.

 

MRI

MRI is the imaging of choice and the ideal scan.

  • Standard protocol: Axial, sagittal, and coronal T1-weighted sequences; axial T2-weighted sequence; axial diffusion, fluid-attenuated inversion recovery (FLAIR), and post-contrast sequences.
  • Precontrast MRI: The tumor will appear hypointense on T1, hyperintense on T2, and intermediate to high intensity on FLAIR signal relative to both white and gray matter. Typically the tumors have heterogeneous signals, and cystic areas are frequently seen.  Calcifications and old hemorrhage are common. 
  • Postcontrast MRI characteristics: Gadolinium enhancement shows great uptake in the soft tissue components of the tumor, but some areas may have poor enhancement.

Axial T1-weighted MRI of an ependymoma in the right frontal lobe: The scan illustrates the tumor’s tendency to develop multiple cysts

Coronal T1-weighted image of an ependymoma in the left frontal lobe: The scan shows a large tumor cyst whose walls are enhancing, solid tumor

 

Coronal and axial T1-weighted contrast images of a recurrent ependymoma: Multiple cysts have developed within the tumor, resulting in a more difficult surgical resection.

 

  • MRI of the spine: MRI of the spine should be obtained to assess for leptomeningeal dissemination.

Perfusion MRI

  • Limited need: Perfusion MRI is not often used.  It may be useful in demonstrating increased blood volume.

Proton MR spectroscopy

  • Limited need initially: The appearance of these tumors is similar to others, showing an elevated choline level and reduced N-acetylaspartate (NAA).
  • Useful later in therapy: Proton MR spectroscopy is useful to try to distinguish tumor recurrence from postoperative changes or postradiation changes.

Nuclear Medicine Tests

  • Not usually required

Electrodiagnostic Tests

  • Not usually required

Neuropsychological Tests

  • Not usually required

Correlation of Tests

  • Evolution of symptoms and appearance on imaging: On the basis of clinical symptoms and radiologic images, the usual differential diagnosis of this type of intracranial tumor, which is solid-cystic in nature, includes pilocytic astrocytoma, pleomorphic xanthoastrocytoma, or ependymoma. Slowly evolving symptoms and a tumor within the fourth ventricle extending out its foramen favors ependymoma.

Your donations keep us going

The ISPN Guide is free to use, but we rely on donations to fund our ongoing work and to maintain more than a thousand pages of information created to disseminate the most up-to-date knowledge in the field of paediatric neurosurgery.

By making a donation to The ISPN Guide you are also indirectly helping the many thousands of children around the world whose treatment depends on well-informed surgeons.

Please consider making a donation today.

Use the app

The ISPN Guide can be used as a standalone app, both on mobile devices and desktop computers. It’s quick and easy to use.

Fully featured

Free registration grants you full access to The Guide and host of featured designed to help further your own education.

Stay updated

The ISPN Guide continues to expand both in breadth and depth. Join our mailing list to stay up-to-date with our progress.