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Radiological Features of Osteogenesis Imperfecta

This page was last updated on April 8th, 2024

General Findings

  • Basilar invagination: There is infolding of the skull base. The upper cervical spine may protrude into the posterior fossa.
  • Deformed brainstem
  • Possible coexistence of hydrocephalus

T2-weighted sagittal MRI of basilar invagination: This MRI taken of a child with osteogenesis imperfecta shows severe basilar invagination with compression of the brainstem.


FLAIR coronal MRI showing basilar invagination: This MRI shows basilar invagination occuring in a child with osteogenesis imperfecta. Note the upward migration of the of the C1 ring displacing the posterior fossa contents.