Understanding of Disease
- 1930 – Cushing’s series published: The first large series of operations for medulloblastoma was reported by Cushing, who had operated on 61 patients with medulloblastoma by 1930, only 5 years after medulloblastoma was described as a pathological entity in 1925 (28). Cushing recognized that survival was longer for patients after radical surgical removal than after biopsy (mean of 17 months after radical surgery vs. 6 months after biopsy).
- 1953 – reported effectiveness of radiation: Prior to the era of modern imaging, radiation therapy, and chemotherapy, medulloblastoma was considered a fatal disease. The first major breakthrough, in 1953, came when Patterson and Farr reported that craniospinal irradiation significantly prolongs survival (29).
- 1990 – reported effectiveness of chemotherapy: In 1990, Evans et al. first reported a randomized trial demonstrating the benefits of chemotherapy added to radiation therapy over radiation therapy alone (23).
- Modern multimodality treatment curative: Modern treatment paradigms incorporating maximal safe surgical resection, craniospinal radiation therapy, and chemotherapy have changed medulloblastoma from a fatal disease to one in which most patients achieve long-term survival.
Please create a free account or log in to read 'History of Management of Medulloblastomas in Children'
Registration is free, quick and easy. Register and complete your profile and get access to the following:
- Full unrestricted access to The ISPN Guide
- Download pages as PDFs for offline viewing
- Create and manage page bookmarks
- Access to new and improved on-page references