Cite

Copy

Tap on and choose 'Add to Home Screen' to create a shortcut app

Tap on and choose 'Add to Home Screen/Install App' to create a shortcut app

Pathology of Cerebellar Astrocytomas in Children

This page was last updated on May 9th, 2017

Pathophysiology

  • W.H.O. grade used to describe: The W.H.O. 4-point grading system is used to describe these tumors, with grade 1 representing the most benign pilocytic astrocytomas; grade 2, the fibrillary astrocytomas; and grades 3 and 4, the malignant astrocytomas.
  • Site of origin: There does not seem to be a preferred location of origin for these tumors.
  • Gross appearance: These tumors tend to have a margin that bends over a short distance with the surrounding normal cerebellar parenchyma.
  • Infiltrative: These tumors tend to infiltrate to a varying degree based on the tumor grade. Low grades do not infiltrate to the degree that higher grades do.

Molecular/Genetic Pathology

Histopathology

Features of cerebellar astrocytomas typically include the following (8):

  • Biphasic pattern with varying proportions of Rosenthal fibers and multipolar cells with microcysts and granular bodies 

Typical biphasic pattern of compact areas and hypocellular areas with microcysts:


Squash preparation of a pilocytic astrocytoma showing Rosenthal fibers and piloid cells:


 

  • Low MIB-1: Low to moderate cellularity with low proliferative (MIB-1) index

Low MIB-1 proliferative index in a pilocytic astrocytoma:


 

  • GFAP positivity

GFAP positivity in cerebellar pilocytic astrocytoma:


Your donations keep us going

The ISPN Guide is free to use, but we rely on donations to fund our ongoing work and to maintain more than a thousand pages of information created to disseminate the most up-to-date knowledge in the field of paediatric neurosurgery.

By making a donation to The ISPN Guide you are also indirectly helping the many thousands of children around the world whose treatment depends on well-informed surgeons.

Please consider making a donation today.

Use the app

The ISPN Guide can be used as a standalone app, both on mobile devices and desktop computers. It’s quick and easy to use.

Fully featured

Free registration grants you full access to The Guide and host of featured designed to help further your own education.

Stay updated

The ISPN Guide continues to expand both in breadth and depth. Join our mailing list to stay up-to-date with our progress.