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Epidemiology for Intramedullary Spinal Cord Tumors in Children

This page was last updated on May 9th, 2017

Incidence and Prevalence

  • Incidence: 170 – 180 IMSCTs arise in North America each year. This lesion represents roughly 4% of tumors that arise in the CNS of children (3).

Age Distribution

  • Even distribution: There is a relatively even distribution of IMSCTs across the ages of childhood and adolescence (10).

Age distribution of IMSCTs in children:

Sex Predilection

  • Even distribution: In the series of Constantini and colleagues, 58% were male and 42% were female (10).

Geographic Distribution

  • No predilection apparent: Data are not available to determine whether there is a geographic predilection for IMSCTs. In the United States there does not seem to be one.

Risk Factors

  • Risk factors: No particular risk factors with regard to environmental or infectious pathogens have been described.

Relationships to Other Disease States and Syndromes

  • NF1: A spinal cord tumor in a child with NF1 is likely an astrocytoma. 
  • NF2: Children with NF2 have an increased incidence of spinal cord ependymomas in particular but astrocytomas and gangliogliomas are also seen.  
  • Hemangioblastomas: The stromal cells lying between the vascular channels of these tumors consistently have lost heterozygosity of the VHL gene and thus it is felt that these cells are implicated in the pathogenesis of the disease (38).

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